陈婷, 贾秋蕾, 胡元会, 褚瑜光. 盐敏感性高血压患者同型半胱氨酸水平与血压及心率变异性的相关性[J]. 心脏杂志, 2021, 33(6): 609-612. DOI: 10.12125/j.chj.202101062
    引用本文: 陈婷, 贾秋蕾, 胡元会, 褚瑜光. 盐敏感性高血压患者同型半胱氨酸水平与血压及心率变异性的相关性[J]. 心脏杂志, 2021, 33(6): 609-612. DOI: 10.12125/j.chj.202101062
    shu
    Ting CHEN, Qiu-lei JIA, Yuan-hui HU, Yu-guang CHU. Relationship between homocysteine (Hcy) level and blood pressure variability (BPV) and heart rate variability (HRV) in patients with salt-sensitive hypertension[J]. Chinese Heart Journal, 2021, 33(6): 609-612. DOI: 10.12125/j.chj.202101062
    Citation: Ting CHEN, Qiu-lei JIA, Yuan-hui HU, Yu-guang CHU. Relationship between homocysteine (Hcy) level and blood pressure variability (BPV) and heart rate variability (HRV) in patients with salt-sensitive hypertension[J]. Chinese Heart Journal, 2021, 33(6): 609-612. DOI: 10.12125/j.chj.202101062
    shu

    盐敏感性高血压患者同型半胱氨酸水平与血压及心率变异性的相关性

    Relationship between homocysteine (Hcy) level and blood pressure variability (BPV) and heart rate variability (HRV) in patients with salt-sensitive hypertension

      摘要
    • 摘要:
        目的  探讨盐敏感性高血压患者同型半胱氨酸(Hcy)水平与血压变异性（BPV）和心率变异性（HRV）之间的关系。
        方法  收集2015年至2016年入住中国中医科学院广安门医院131例盐敏感高血压患者，以Hcy≥15 μmol/L为Hcy升高组，<15 μmol/L为正常组。通过对患者血压及心率的动态监测，采用SPSS 26.0统计学软件对数据进行处理，分析比较两组间血压和心率变异性相关参数。
        结果  两组患者的年龄和性别构成的差异均无统计学意义。升高组Hcy水平显著高于正常组（P<0.01）；升高组24 h平均收缩压（24HASBP）、24 h平均舒张压（24HADBP）、24 h收缩压变异性(24HSBPV)和24 h舒张压变异性(24HDBPV)均显著高于正常组（P<0.01，P<0.01，P<0.05，P<0.01）；而升高组心率变异性指标所有相邻心搏R-R间期之差的标准差(RMSDD)、所有心搏的R-R间期的标准差(SDNN)、每5 min心搏 R-R 间期均值的标准差(SDANN)则显著低于正常组（P<0.05，P<0.01，P<0.01）。其中Hcy水平与24HADBP、24HDBPV、RMSSD、SDNN之间有相关性（P<0.01），其中与RMSSD和SDNN呈负相关。且多元线性逐步回归分析显示，上述二者与Hcy水平之间具有显著影响（P<0.05）。
        结论  盐敏感性高血压患者Hcy水平与BPV和HRV之间具有相关性。

       

      Abstract:
        AIM   To investigate the relationship between homocysteine (Hcy) level and blood pressure variability (BPV) and heart rate variability (HRV) in patients with salt-sensitive hypertension.
        METHODS  131 patients with salt-sensitive hypertension admitted to Guang’anmen Hospital, China Academy of Chinese Medical Sciences from 2015 to 2016 were selected. Hcy≥15 mol/L served as Hcy increased group, while <15 mol/L served as normal group. Through dynamic monitoring of patients’ blood pressure and heart rate, statistical software was used to analyze and compare the related parameters of blood pressure and heart rate variability between the two groups, and further determine the influencing factors of Hcy level.
        RESULTS  Significant difference was found in BPV (24hASBP, 24hADBP, 24hSBPV, 24hDBPV) and HRV (RMSDD, SDNN, SDANN) in Hcy increased group (P<0.01, P<0.01, P<0.05, P<0.01) and the difference between the two groups was statistically significant. Hcy level was correlated with 24hADBP, 24hDBPV, RMSSD and SDNN (P<0.01) and it was negatively correlated with RMSSD and SDNN in heart rate variability. Moreover, multiple linear stepwise regression analysis showed that the above two levels had a significant influence on Hcy level. (P<0.05, P<0.01, P<0.01).
        CONCLUSION  Hcy level is correlated with blood pressure variability and heart rate variability in patients with salt-sensitive hypertension.

       

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