孙雪, 王虹, 肖双, 梁浩, 高海超. CHD并发EH患者MHR与冠脉狭窄程度的关系[J]. 心脏杂志, 2021, 33(3): 255-260. DOI: 10.12125/j.chj.202012072
    引用本文: 孙雪, 王虹, 肖双, 梁浩, 高海超. CHD并发EH患者MHR与冠脉狭窄程度的关系[J]. 心脏杂志, 2021, 33(3): 255-260. DOI: 10.12125/j.chj.202012072
    shu
    Xue SUN, Hong WANG, Shuang XIAO, Hao LIANG, Hai-chao GAO. Relationship between MHR and coronary artery stenosis in patients with CHD combined with EH[J]. Chinese Heart Journal, 2021, 33(3): 255-260. DOI: 10.12125/j.chj.202012072
    Citation: Xue SUN, Hong WANG, Shuang XIAO, Hao LIANG, Hai-chao GAO. Relationship between MHR and coronary artery stenosis in patients with CHD combined with EH[J]. Chinese Heart Journal, 2021, 33(3): 255-260. DOI: 10.12125/j.chj.202012072
    shu

    CHD并发EH患者MHR与冠脉狭窄程度的关系

    Relationship between MHR and coronary artery stenosis in patients with CHD combined with EH

      摘要
    • 摘要:
        目的  探讨冠心病(coronary heart disease，CHD)并发原发性高血压(enssential hypertension, EH)患者单核细胞/高密度脂蛋白胆固醇比值(monocyte/high density lipoprotein cholesterol ratio, MHR )与冠脉病变严重程度的相关性。
        方法  连续选取疑诊CHD并于承德医学院附属医院行冠脉造影的患者405例，根据造影结果及既往病史，分为健康对照组（n=80），单纯CHD组（n=95），单纯EH组（n=80）和CHD并发EH组（n=150）。根据Gensini评分将CHD并发EH组患者分为A组（Gensini评分<15分）、B组（Gensini评分15～30分）和C组（Gensini评分>30分）。收集患者的一般临床资料并计算MHR。
        结果  CHD并发EH组MHR水平高于其他三组（P<0.01）。CHD并发EH组及单纯CHD组的MHR水平与Gensini评分呈显著正相关（r=0.234，P<0.01；r=0.266，P<0.01）。Logistic回归分析发现MHR水平升高，是CHD并发EH组Gensini评分>30分的独立危险因素。MHR预测CHD并发EH组Gensini评分>30分的ROC曲线下面积为0.742（95%CI：0.658～0.827，P<0.01），对应灵敏度为88.20%，特异度为60.00%，MHR预测CHD并发EH组Gensini评分>30分的最佳切点为0.352。
        结论  MHR对CHD并发EH患者的冠脉病变严重程度有良好的预测价值。

       

      Abstract:
        AIM  To explore the relationship between the monocyte/high density lipoprotein cholesterol ratio (MHR) and the severity of coronary artery disease in patients with coronary heart disease and essential hypertension.
        METHODS  Four hundred and five patients with suspected coronary heart disease who underwent coronary angiography in our hospital were continuously selected. According to the results of the angiography and past medical history, the patients were divided into coronary heart disease combined with hypertension group (n=150), simple coronary heart disease group (n=95), simple hypertension group (n=80) and healthy control group (n=80). The degree of coronary artery disease in patients with coronary heart disease was evaluated by Gensini score. According to Gensini score, patients with coronary heart disease and hypertension were divided into three groups: A (Gensini score <15 points), B (Gensini score 15-30 points) and C (Gensini score> 30 points). General clinical data of each patient were collected and MHR was calculated.
        RESULTS  The MHR level in the coronary heart disease combined with hypertension group was higher than that in the other three groups (P<0.001). The MHR levels in the coronary heart disease combined with hypertension group and the simple coronary heart disease group were significantly positively correlated with Gensini score (r=0.234, P<0.01; r=0.266, P<0.01). Logistic regression analysis showed that elevated MHR level was an independent risk factor for the Gensini score in the coronary heart disease combined with hypertension group>30 points. The area under the ROC curve of MHR in the coronary heart disease combined with hypertension group > 30 points was 0.742 (95% CI: 0.658～0.827, P<0.01). The best cut point was 0.352, the corresponding sensitivity was 88.20% and the specificity was 60.00%. The best cut point for MHR to predict the Gensini score of coronary heart disease and hypertension was 0.352.
        CONCLUSION  MHR has a good predictive value for the severity of coronary artery disease in patients with coronary heart disease and hypertension.

       

      • HTML全文
      • 参考文献(14)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回