Abstract: Exercise brings multiple benefits for cardiovascular system and it has been recommended as one of the therapeutic approaches for myocardial infarction. Owing to the complexity of exercise in regulating myocardial infarction, its specific mechanism has not been fully elucidated. Recently, it has been found that the expressions of a variety of miRNAs have changed during exercise and it has been further found that exercise-induced miRNAs play an important role in the course of myocardial infarction. Therefore, this article focuses on summarizing the regulatory effect of miRNAs on myocardial infarction under exercise regulation and analyzing its possible mechanism, in order to provide a more in-depth theoretical basis for the clinical application of exercise training for myocardial infarction.