Abstract: Myocardial ischemia reperfusion injury (MIRI) induces cardiomyocytes death and leads to loss of cardiac functions. With the continuous development of bioinformatics and gene sequencing technology, it has been discovered that more and more non-coding RNAs (ncRNAs) with biological functions are involved in the occurrence and development of MIRI, mainly including microRNA, long non-coding RNA and circRNA. To clarify the pathogenesis of ncRNAs in MIRI is helpful to explore new treatment strategies for ischemic cardiovascular disease.