AIM   To analysis the related factors of hypertrophic cardiomyopathy (HCM) combined with atrial fibrillation (AF).

  METHODS   A total of 395 cases of hypertrophic cardiomyopathy meeting the criteria were selected. They were divided into HCM with AF group (AF group, n=190) and without AF group (NAF group, n=205). Observe the general information, biochemical indicators and echocardiographic indicators, and logisitic multivariate regression analysis was used to evaluate the risk factors of HCM combined with AF.

  RESULTS   Compared with the HCM-NAF group, the HCM-AF group was older and had a longer disease duration(all P<0.05). Uric acid, Cystatin C(Cys-C), pro-brain natriuretic peptide(pro-BNP), troponin T(cTnT), glycated hemoglobin, homocysteine(Hcy), left atrium(LA) diameter, right ventricular diameter, The mitral valve regurgitation was higher (P<0.05 or P<0.01), and Low density lipoprotein cholesterol(LDL-C), Triglyceride(TG), Glomerular filtration rate(eGFR), ejection fraction, and left ventricular outflow tract pressure gradient were lower (all P<0.01), the history of smoking, cerebral infarction, palpitations and cardiac function with grade III/IV were higher (all P<0.01), the other indicators were no significantly differences. Multivariate logisitic regression analysis showed the history of smoking, cardiac function with grade III/IV, low eGFR, and LA diameter were significantly associated with AF in HCM patients(all P≤0.01).

  CONCLUSION   The history of smoking, poor cardiac function grading, low eGFR, and LA diameter may be the related factors of HCM combined with AF.