袁勇, 孔凡斌, 吉永, 高辉. 动脉粥样硬化危险因素视黄醇结合蛋白4与血脂的相关性[J]. 心脏杂志, 2021, 33(1): 53-56. DOI: 10.12125/j.chj.202007014
    引用本文: 袁勇, 孔凡斌, 吉永, 高辉. 动脉粥样硬化危险因素视黄醇结合蛋白4与血脂的相关性[J]. 心脏杂志, 2021, 33(1): 53-56. DOI: 10.12125/j.chj.202007014
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    Yong YUAN, Fan-bin KONG, Yong JI, Hui GAO. Correlation between serum retinol binding protein 4 and lipid level in carotid artery atherosclerosis[J]. Chinese Heart Journal, 2021, 33(1): 53-56. DOI: 10.12125/j.chj.202007014
    Citation: Yong YUAN, Fan-bin KONG, Yong JI, Hui GAO. Correlation between serum retinol binding protein 4 and lipid level in carotid artery atherosclerosis[J]. Chinese Heart Journal, 2021, 33(1): 53-56. DOI: 10.12125/j.chj.202007014
    shu

    动脉粥样硬化危险因素视黄醇结合蛋白4与血脂的相关性

    Correlation between serum retinol binding protein 4 and lipid level in carotid artery atherosclerosis

      摘要
    • 摘要:
        目的  探讨颈动脉粥样硬化患者血清视黄醇结合蛋白4（RBP4）与血脂的关系，为动脉粥样硬化的临床诊治提供依据。
        方法  选取2017年7月至2018年11月在昆明医科大学附属延安医院就诊的患者共236例，根据超声测量颈动脉中层内膜厚度（IMT），将入选病例中IMT<1 mm的患者纳入非AS组（共39例），IMT≥1 mm的患者纳入AS组（共197例），抽取入选病例静脉血，离心分离血清测定RBP4和TC、TG、HDL-C、LDL-C、APOA1、APOB。应用SPSS17进行统计学分析。
        结果  AS组的RBP4、TG和LDL-C均显著升高（P<0.01），HDL-C和APOA1则显著减低（P<0. 01）。logistics多因素分析得到AS的独立相关因素是HDL-C、LDL-C、APOA1。Spearman单因素相关分析得出：RBP4与TG、HDL-C和APOA1有相关关系，其中RBP4 与TG成正相关，与HDL-C和APOA1成负相关。回归分析得到RBP4与TG线性回归方程为：RBP4=32.07TG-15.30(P<0.05)，复相关系数R=0.745（P<0.05），且RBP4与TG分层回归后复相关系数更高；RBP4与HDL-C和APOA1均是三次方程曲线模型最佳，回归方程分别为：RBP4=−190.84HDL-C3+963.61HDL-C2−1493.03HDL-C+746.06(P<0.05)和RBP4=−342.66APOA13+1571.76APOA12−2372.02APOA1+1212.93(P<0.05)，复相关系数分别为R=0.861（P<0.05）和R=0.670（P<0.05）。
        结论  颈动脉粥样硬化患者RBP4与TG有直线分层关系，与HDL-C和APOA1有曲线相关关系。

       

      Abstract:
        AIM  To investigate the relationships between serum retinol binding protein 4 (RBP4) levels and blood lipid in carotid artery atherosclerosis patients, so as to provide evidence for clinical diagnosis and treatment of atherosclerosis.
        METHODS  Included in this study were 236 patients in Affiliated Yan′an Hospital of Kunming Medical University. According to carotid artery middle membrane thickness (IMT) measured by ultrasound, 39 cases were assigned to IMT non-thickening group (IMT<1 mm) and 197 cases were assigned to IMT thickening group (IMT≥1 mm). Serum RBP4, total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (APOA1) and apolipoprotein B were determined. The data were analyzed by SPSS17.0 statistical software.
        RESULTS  Serum RBP4, TG and LDL-C in IMT thickening group were significantly higher than those in IMT non-thickening group (P<0.01), Logistics analysis showed that HDL-C, LDL-C and APOA1 were independent correlation factors of AS. Spearman single-factor correlation analysis showed that there was a positive correlation between serum RBP4 and TG, HDL-C and APOA1. There was linear regression between serum RBP4 and TG (RBP4=32.07 TG-15.30, P<0.05) and the complex correlation coefficient was R=0.745 (P<0.05). Moreover, there was a complex correlation between RBP4 and TG by stratified regression analysis. There was curve regression between serum RBP4, HDL-C and APOA1 (RBP4=-190.84HDL-C3+963.61HDL-C2-1493.03 HDL-C+746.06, P<0.05) and (RBP4=−342.66APOA13+1571.76APOA12−2372.02 APOA1+1212.93, P<0.05). The complex correlation coefficients were R=0.861 (P<0.05) and R=0.670 (P<0.05).
        CONCLUSION  There is a linear stratified relationship between RBP4 and TG in carotid atherosclerosis patients and there is curvilinear correlation between RBP4 and HDL-C and APOA1.

       

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