Abstract: Cardiac amyloidosis is characterized by misfolded autologoue protein infiltrating into myocardial tissues, resulting in cardiac dysfunction and structure change. Although considerable progress in understanding the pathophysiology of cardiac amyloidosis, the diagnosis of cardiac amyloidosis is often overlooked in early stage. This review is focused on early diagnosis detection and treatment improvement in light chain amyloidosis (AL), senile systemic amyloidosis (wtATTR), and hereditary (familial) amyloidosis (mATTR), which will open up new ways for cardiac amyloidosis therapy.