陆鑫, 张华, 郑若龙, 陈新军, 杨增芯, 朱丽丽. 单核细胞/高密度脂蛋白胆固醇比值与PCI术后非罪犯血管病变进展的相关性及其应用价值[J]. 心脏杂志, 2020, 32(5): 476-479. DOI: 10.12125/j.chj.202005003
    引用本文: 陆鑫, 张华, 郑若龙, 陈新军, 杨增芯, 朱丽丽. 单核细胞/高密度脂蛋白胆固醇比值与PCI术后非罪犯血管病变进展的相关性及其应用价值[J]. 心脏杂志, 2020, 32(5): 476-479. DOI: 10.12125/j.chj.202005003
    shu
    Xin LU, Hua ZHANG, Ruo-long ZHENG, Xin-jun CHEN, Zeng-xin YANG, Li-li ZHU. Correlation between monocyte to HDL-C ratio and non-culprit vessel lesion progression after percutaneous coronary intervention in patients[J]. Chinese Heart Journal, 2020, 32(5): 476-479. DOI: 10.12125/j.chj.202005003
    Citation: Xin LU, Hua ZHANG, Ruo-long ZHENG, Xin-jun CHEN, Zeng-xin YANG, Li-li ZHU. Correlation between monocyte to HDL-C ratio and non-culprit vessel lesion progression after percutaneous coronary intervention in patients[J]. Chinese Heart Journal, 2020, 32(5): 476-479. DOI: 10.12125/j.chj.202005003
    shu

    单核细胞/高密度脂蛋白胆固醇比值与PCI术后非罪犯血管病变进展的相关性及其应用价值

    Correlation between monocyte to HDL-C ratio and non-culprit vessel lesion progression after percutaneous coronary intervention in patients

      摘要
    • 摘要:
        目的  探讨单核细胞/高密度脂蛋白胆固醇比值（MHR）与PCI术后非罪犯血管病变（NCL）进展的相关性。
        方法  收集江阴市人民医院2016年1月～2018年12月行PCI术并在2019年12月之前进行造影复查的135例患者的临床资料。根据造影情况分为NCL进展组（62例）和NCL非进展组（73例）。比较2组的一般资料，分析MHR与NCL进展的相关性。
        结果  NCL进展组apoB、空腹血糖、MHR水平显著高于NCL无进展组（P<0..05）。NCL进展组复查造影的狭窄程度显著大于非进展组，再次PCI也明显多于非进展组（均P<0.01）。以MHR值0.375为界值预测NCL进展最佳，其敏感度及特异度分别为60%及56%,曲线下面积为0.604（95%可信区间：0.510−0.699）。MHR水平（比值比=2.217，95%可信区间：1.092−4.501，P<0.05）及空腹血糖水平（比值比=1.900，95%可信区间：1.020−3.540，P<0.05）是NCL进展的危险因素。
        结论  MHR与PCI术后患者NCL进展有相关性，且有一定应用价值。

       

      Abstract:
        AIM   To analyze the relationship between monocyte to HDL-C ratio (MHR) and non-culprit vessel lesion (NCL) progression with percutaneous coronary intervention (PCI) in patients.
        METHODS   Clinical data of 132 patients who had percutaneous coronary intervention from January 2016 to December 2018 and had reexamination of coronary angiography before December 2019 in Jiangyin People's Hospital.They were divided into NCL progression group (62 cases) and NCL progression-free group (73 cases).Basic information and the correlation between MHR and NCL progression were analyzed.
        RESULTS   Level of ApoB,fasting blood glucose and MHR in NCL progression group were significantly higher than those in NCL progression-free group (all P<0.05). The degree of stenosis in NCL progression-free group was significantly higher than that in NCL progression-free group, and PCI was also significantly higher than NCL progression-free group (all P<0.01). Receiver operating characteristic curve showed that the boundary point of MHR to predict NCL progression was 0.375 with the sensitivity and specificity at 60% and 56% respectively,the area under curve (AUC) were 0.604 (95% confidence interval:0.510～0.699). Logistic regression showed that MHR (odds ratio=2.217, 95% confidence interval:1.092～4.501, P<0.05) and fasting blood glucose (odds ratio=1.900, 95% confidence interval:1.020～3.540, P<0.05) were risk factor.
        CONCLUSION   There is a correlation between MHR and NCL progression after PCI in patients.

       

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