Abstract: With the widespread use of immune checkpoint inhibitors, adverse events induced by immune checkpoint inhibitors are a great challenge for clinicians. Cardiotoxicity (especially myocarditis) is one of such serious adverse event. Because of its low incidence, we know little about the cardiotoxicity caused by immune checkpoint inhibitors. The specific mechanism, predictive factors, risk factors, managements and treatments are also not clear yet. This review summarizes possible mechanism, risk factors, cardiotoxicity types, managements and treatments of cardiotoxicity caused by immune checkpoint inhibitors in hope of attracting more doctors’ attention and providing much better treatment guidance for patients.