糖尿病性心肌病变患者胰岛素强化治疗前后氧化应激水平的变化

Effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy

摘要: 目的:评价糖尿病性心肌病(DCM)患者胰岛素泵强化治疗前后氧化应激水平的变化。方法： 30例DCM患者采用胰岛素泵强化治疗，治疗达标前后进行超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）、丙二醛（MDA）水平测定并进行比较。结果：胰岛素泵强化治疗后，患者血浆中的SOD、GSH-PX水平明显上升（P<0.01）、MDA水平明显下降（P<0.01）。空腹血糖、餐后2 h血糖、胰岛素抵抗指数、总胆固醇、三酰甘油、低密度脂蛋白、游离脂肪酸明显降低（P<0.05）,胰岛素分泌功能指数明显上升（P<0.05）。结论： DCM患者使用胰岛素泵强化治疗后氧化应激水平明显降低。

Abstract: AIM:To evaluate the effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy (DCM). METHODS: Thirty patients with DCM were treated with continuous subcutaneous insulin injection. SOD, GSH-PX and MDA were compared before and after insulin pump therapy. RESULTS: After treatment, SOD and GSH-PX levels significantly increased, whereas the MDA level significantly decreased (P<0.01). CONCLUSION: Oxidative stress level in DCM patients significantly decreases after continuous subcutaneous insulin injection treatment.