Abstract: Recent research has found that several disease conditions are characterized by a thromboinflammatory state in which interactions of blood cells and components with the vascular wall perpetuate both thrombotic and inflammatory pathways. Targeting these pathways may be of benefit in inflammatory conditions and cardiovascular diseases. Ongoing clinical trials should provide insight into the hypothesis that the thromboinflammatory state contributes to adverse clinical outcomes. This article summarizes the molecular and cellular links between inflammation and thrombosis in the context of cardiovascular and other thromboinflammatory diseases.