对比剂碘克沙醇对轻中度肾功能不全伴Ⅱ型糖尿病患者血清肌酐的影响

    Effect of iodixanol on serum creatinine of patients with mild or moderate renal dysfunction and type II diabetes

      摘要
    • 摘要: 目的:观察对比剂碘克沙醇(威视派克) 对肾功能不全并发糖尿病患者血清肌酐的影响，以探讨其临床使用的安全性。方法：选取2009年1月20日~2010年4月20日于我院行心血管造影的Ⅱ型糖尿病并发轻-中度肾功能不全的患者84例,观察术前、术后各项指标的变化，对造影前后数据进行配对资料统计分析。结果：术后3 d血清肌酐（SCr）较基线水平显著增加［(97±20) μmol/L vs.(95±20) μmol/L,P<0.05］,术后2 d SCr:(95±21) μmol/L,术后3 d较术后2 d SCr略有升高（P<0.05）。结论：碘克沙醇用于Ⅱ型糖尿病并发轻-中度肾功能不全的患者仅轻度增加SCr，使用是安全的。

       

      Abstract: AIM:To observe the effect of iodixanol on serum creatinine of patients with mild or moderate renal dysfunction and type II diabetes (T2D) and to examine the safety of iodixanol. METHODS: Included in the study were 84 patients with mild or moderate renal dysfunction and T2D undergoing cardiovascular angiography at the Wuhan Asian Heart Hospital. Paired data before and after cardiovascular angiography were compared using t test. RESULTS: Serum creatinine (Scr) at 3 days postoperatively significantly increased (2.5%) compared with baseline ［(97±20) μmol/L vs. (95±20) μmol/L, P<0.05］. Scr at 3 days postsurgery significantly increased (2.1%) compared with that 2 days postsurgery ［(97±20) μmol/L vs. (95±21) μmol/L, P<0.05］. CONCLUSION: Lodixanol can be used in patients with mild or moderate renal dysfunction and type II diabetes and only slightly increases Scr.

       

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