Abstract: AIM To evaluate the medium and long term efficacy and safety of China-made septal occluder in the transcatheter closure of congenital heart disease. METHODS Seventy-one patients with congenital heart disease, including 27 cases of PDA, 22 cases of ASD, 23 cases of VSD and 1 case of VSD combined with ASD, were treated with China-made septal occluder by transcatheter closure. All the patients were followed up for 1 to 5 years and were evaluated in terms of efficacy and safety. RESULTS Transcatheter closure was successful in 69 patients but it failed in cases, one with ASD and one with VSD. Five patients had minor to moderate residual shunt the time after the transcatheter closure but no residual shunt was observed 1 month after the operation. One patient with VSD presented III A-V block and he recovered completely after treatment. No other complications were observed in the patients during the 1-to-5-year follow up. CONCLUSION China-made septal occluder is safe and effective for transcatheter closure of congenital heart disease.