冠心病患者外周血总IgE水平的变化

    Changes of peripheral blood levels of total Immunoglobulin E in patients with coronary heart disease

      摘要
    • 摘要: 目的 评估不同类型冠心病（CHD）患者外周血中总免疫球蛋白E（IgE）的水平变化意义。方法 选取CHD患者56例:急性心肌梗死（AMI）患者22例，不稳定型心绞痛（UA）患者17例以及17例稳定型心绞痛（SA）患者。对照组为年龄匹配的健康个体。所有受试者均无家族及个人过敏史。采用ELISA法测定血清总IgE的水平。结果 与对照组［IgE水平(52±30)kU/L］相比，不同类型CHD患者血清总IgE的水平［AMI组：(179±159)kU/L,P<0.01；UA组：(131±78)kU/L,P<0.05；SA组：(127±65)kU/L,P<0.05］均明显增高。AMI患者发病后1，7，14，30 d血清总IgE的水平没有显著差异。结论 各种类型冠心病患者外周血总IgE的水平均升高。

       

      Abstract: AIM To evaluate the changes of the total immunoglobulin(Ig)E concentration in patients with different forms of coronary heart disease (CHD) and the dynamic changes of serum IgE concentration in patients with acute myocardial infarction (AMI) and to explore the possible difference of total IgE concentration between CHD patients and healthy control. METHODS The study included 56 patients: 22 AMI patients, 17 patients with unstable angina (UA) and 17 patients with stable angina pectoris. The control group consisted of 17 healthy, age-matched individuals. All the subjects have no personal and family history of allergy. Total serum IgE concentration was measured with Enzyme-Linked Immunosorbent Assay (ELISA). RESULTS In patients with coronary heart diseases ［AMI group: (179±159)kU/L, P<0.01; UA group: (131±78)kU/L, P<0.05; SA group: (127±65)kU/L, P<0.05］, significantly increased concentrations of serum immunoglobulin E were found, as compared to those in the control group ［(52±30)kU/L］. Changes of IgE serum concentration on the 1st day, 7th day, 14th day and 30th day after AMI did not reveal any significant differences. CONCLUSION The total IgE concentration in patients with CHD increases.

       

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