Abstract: Coronary plaque is the basic pathological change of coronary heart disease. Acute coronary syndrome occurs after plaque rupture. Current research mainly focuses on atherosclerotic plaque intervention and many studies have proven that non-surgical treatments such as drugs, endothelial progenitor cell transplantation, and lifestyle intervention can reduce coronary atherosclerotic plaque in early stages. This article introduces the progress in non-surgical treatments and mechanisms of coronary atherosclerotic plaque.