Abstract: AIM To observe whether the corresponding headchest (HC) lead electrocardiogram (HCECG) is more exact and accordant than the limb lead of routine 12lead electrocardiogram (RLECG) in the healthy subjects. METHODS HCECGs and RLECGs were recorded simultaneously in the healthy subjects and the normal diagnosis of each HCECG and RLECG was confirmed by the analyses of 2 senior physicians of clinical electrophysiology. The comparison was made between RLECGs and HCECGs, including 2 groups (I, II, III to CL2, CL4, CL6 and HV7, HV8, HV9), (aVR, aVL, aVF to HR3, HO, HL3 and AR3, HR7, AL3 ) respectively. ECGs were classified into the normal and false change according to the shape of P, QRS and T waves. The chisquare test was performed for statistical difference between the HCECGs and RLECGs in healthy subjects. RESULTS Among the 120 cases of healthy subjects, deformed ECGs appeared in III, aVR and aVL leads, for biphasic or inverted P wave 31.6% in III, 100% in aVR, wide or deep Q wave 29.1% in III, flat or inverted T wave 26.7% in III, 100% in aVR, 23.3% in aVL. However, in corresponding HClead inverted P or T wave appeared only in AR3 for 18.3％. Statistical difference was found between the results of the HCECGs and those of the RLECGs (P<0.01). CONCLUSION The false changes of HCECG may be significantly lower than those of RLECG in healthy subjects.