血清同型半胱氨酸高水平的老年高血压病患者尿微量白蛋白的变化

Changes of urinary microalbumin levels in elderly patients with essential hypertension and high homocysteine levels

摘要: 目的:了解老年高血压病患者血清同型半胱氨酸（homocysteine,Hcy）高水平的老年高血压病患者尿微量白蛋白的变化。方法：对120例老年高血压病患者进行血清Hcy的测定及动态血压的测定，高Hcy组59例，正常Hcy组61例，比较两组尿微量白蛋白的水平。结果：高Hcy组患者尿微量白蛋白显著高于正常Hcy组［(22±4) μg/min vs.(15±4) μg/min，P<0.01］。结论：高Hcy组高血压病患者尿微量白蛋白升高，Hcy加重高血压病患者的肾损害。

Abstract: AIM:To explore the changes of urinary microalbumin levels in elderly patients with essential hypertension with high homocysteine levels. METHODS: Serum homocysteine and ambulatory blood pressure were measured in 120 elderly patients with hypertension. The patients were divided into two groups: high Hcy group (n=59) and control group (n=61), and urinary microalbumin was compared between groups. RESULTS: The urinary microalbumin in high Hcy group was higher than in control group ［(22±4) μg/min vs.(15±4) μg/min, P<0.01］. CONCLUSION: High urinary microalbumin in Hcy group suggests that Hcy increases renal damage in elderly patients with essential hypertension.