Abstract: AIM:To explore the predictive value of admission platelet-leukocyte-aggregate (PLA) to major adverse cardiac events (MACE) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). METHODS: According to clinical diagnosis, 114 hospitalized patients were divided into two groups: NSTE-ACS group (n=72) and control (CTL) group (n=42), and clinical data of the two groups were collected and analyzed. NST-ACS group was further divided into low-risk (LR) group and high-risk (HR) group according to the global registry of acute coronary events (GRACE) scores. The platelet-monocyte-aggregate (PMA), the platelet-neutrophile-aggregate (PNA) and the platelet- lymphocyte-aggregate (PlyA) were compared between LR group and HR group. Moreover, the correlations of PLA, PMA, PNA and PlyA to the GRACE scores were also evaluated and the receiver operating characteristic (ROC) curve was used to assess the value of PLA in predicting short-term MACE in patients with the NSTE-ACS. RESULTS: Compared with those in CTL group, PLA, PMA, PNA and PlyA in the NSTE-ACS group were significantly higher (P<0.01), and PLA, PMA, PNA and PlyA in high-risk group were also markedly higher than those in low-risk group (P<0.01). Spearman correlation analysis showed that the GRACE scores was positively correlated with PLA, PMA, PNA and PlyA (r= 0.617, 0.634, 0.527 and 0.492, P<0.05). During the follow up, MACE occurred in 13.89% (10/72) of the NST-ACS patients. The ROC curve showed the area under curve (AUC) of admission PLA was 0.753 (P<0.05, 95%CI: 0.737-0.779) in predicting the short-term risk of MACE. CONCLUSION: Admission PLA is a good predictor for short-term MACE in patients with NSTE-ACS.