Abstract: AIM:To study the effect of enalapril, bisoprolol and spironolactone on chronic heart failure (CHF) caused by rheumatic heart disease (RHD). METHODS: Eighty six RHD patients with CHF were randomly divided into control group (n=43) and experimental group (n=43). The experimental group was treated with enalapril, bisoprolol and spironolactone, whereas the control group was treated with a conventional regimen. RESULTS: Left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) in the experimental group were significantly lower than in the control group. Left ventricular ejection fraction in the experimental group was much higher (P<0.05). CONCLUSION: Combination therapy of enalapril, bisoprolol and spironolactone has a better effect on patients with CHF caused by RHD and inhibits ventricular remodeling.