Abstract: High-altitude environments, characterized by low atmospheric pressure and chronic hypoxia, exert profound effects on the cardiovascular system, particularly the pulmonary vasculature and right heart function. Given the limitations of single-modality imaging, a multimodal approach is essential for comprehensive assessment and early detection of these pathological changes. This review explores the integrated role of electrocardiography (ECG), echocardiography, computed tomography (CT), and cardiac magnetic resonance (CMR) in the early warning, diagnosis, and therapeutic evaluation of high-altitude cardiovascular diseases. By synthesizing insights from these imaging techniques, this article aims to facilitate early detection and timely clinical intervention of high-altitude cardiovascular diseases.