血清perilipin-5和STIM1对冠心病患者冠状动脉病变程度的评估价值

    Value of serum perilipin-5 and STIM1 levels in evaluating the severity of coronary artery disease in patients with coronary heart disease

      摘要
    • 摘要:
      目的 探究冠心病患者血清脂滴蛋白-5（perilipin-5）和基质相互作用分子1（STIM1）水平对冠状动脉病变程度的评估价值。
      方法 选取2022年6月～2024年6月共216例冠心病患者为观察组，选择同期体检健康志愿者216例为对照组。采用酶联免疫吸附（ELISA）法对所有血清样本perilipin-5和STIM1表达水平进行检测；对冠心病患者血清perilipin-5和STIM1水平与Gensini评分相关性进行Pearson分析；多因素Logistic回归分析识别轻度冠状动脉病变冠心病患者向中重度病变进展相关因素；绘制受试者工作特征（ROC）曲线评估血清中perilipin-5和STIM1水平在诊断冠心病患者中重度冠状动脉病变中的有效性。
      结果 与对照组相比，观察组患者血清perilipin-5表达水平显著降低，STIM1表达水平显著增加（均P<0.01）；Pearson相关性分析结果表明冠心病患者血清perilipin-5水平与Gensini评分呈负相关（rs=−0.483），血清STIM1水平则呈正相关（rs=0.446）（均P<0.01）；与轻度组患者相比，中重度组患者在总胆固醇、甘油三酯、低密度脂蛋白胆固醇和STIM1均升高（均P<0.01），高密度脂蛋白胆固醇、perilipin-5均降低（均P<0.01）。多因素Logistic分析结果表明总胆固醇（P<0.01）、甘油三酯（P<0.05）、高密度脂蛋白胆固醇（P<0.01）、低密度脂蛋白胆固醇（P<0.01）、perilipin-5（P<0.01）和STIM1（P<0.01）与冠状动脉病变轻度冠心病患者进展为中重度有关，可能是病情进展影响因素。ROC曲线分析表明，血清perilipin-5、STIM1二者联合诊断中重度冠状动脉病变冠心病患者曲线下面积（AUC）值为0.891，显著大于perilipin-5和STIM1（Z=2.166、4.173，均P<0.05）单独诊断。
      结论 冠心病患者血清perilipin-5表达水平下降，STIM1表达水平增加，二者联合对冠状动脉病变程度具有较高的评估价值。

       

      Abstract:
      AIM  To explore the value of serum perilipin-5 and stromal interaction molecule 1 (STIM1) levels in evaluating the severity of coronary artery disease in patients with coronary heart disease.
      METHODS A total of 216 patients with coronary heart disease from June 2022 to June 2024 were selected as the observation group, and 216 healthy volunteers who underwent physical examinations within the same time period were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was applied to detect the expression levels of perilipin-5 and STIM1 in all serum samples. Pearson analysis was applied to analyze the correlation between serum perilipin-5, STIM1 levels and Gensini score in patients with coronary heart disease. Multivariate logistic regression was applied to analyze the factors influencing the progression of mild coronary heart disease to moderate to severe levels in patients. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic value of serum perilipin-5 and STIM1 levels for the moderate to severe coronary artery disease in patients.
      RESULTS Compared with the control group, the expression level of serum perilipin-5 in the observation group was significantly reduced, while the expression level of STIM1 was significantly increased (both P<0.01); The Pearson correlation analysis results showed that the serum level of perilipin-5 in patients with coronary heart disease was negatively correlated with Gensini score (rs=−0.483), while the serum level of STIM1 was positively correlated (rs=0.446) (both P<0.01); Compared with the mild group patients, the moderate to severe group patients showed an increase in total cholesterol, triglycerides, low-density lipoprotein, and STIM1 (all P<0.01), while high-density lipoprotein and perilipin-5 decreased (all P<0.01). The results of multivariate logistic analysis showed that total cholesterol (P<0.01), triglycerides (P<0.05), high-density lipoprotein cholesterol (P<0.01), low-density lipoprotein cholesterol (P<0.01), perilipin-5 (P<0.01), and STIM1 (P<0.01) were associated with the progression of mild coronary heart disease to moderate to severe levels, which may be factors affecting disease progression. ROC curve analysis showed that the combined diagnosis of serum perilipin-5 and STIM1 for patients with moderate to severe coronary artery disease had an area under the curve (AUC) value of 0.891, which was significantly higher than the individual diagnosis of perilipin-5 and STIM1 (Z=2.166, 4.173, both P<0.05).
      CONCLUSION The expression level of serum perilipin-5 decreases and the expression level of STIM1 increases in patients with coronary heart disease. The combination of the two has high value for evaluating the severity of coronary artery disease.

       

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