κ-阿片受体在低氧性肺动脉高压中的作用

Role of kappa-opioid receptors in hypoxic pulmonary hypertension

摘要: 低氧性肺动脉高压（HPH）是指由于低氧引起血管内皮细胞损伤，导致血管内皮合成和分泌的各种血管舒缩因子平衡失调，进而引发早期的肺血管收缩和后期的肺血管重塑的病理现象，其发生机制极为复杂。然而目前临床上尚无根治HPH的方法。对于参与HPH的调控机制及干预研究已成为亟待解决的科学难题。本文综述了κ-阿片受体在HPH的发生和发展中所发挥的作用，旨在介绍κ-阿片受体在相关研究领域的最新进展。

Abstract: Hypoxic pulmonary hypertension (HPH) is a pathological phenomenon in which hypoxia causes damage to vascular endothelial cells, leading to an imbalance in the synthesis and secretion of various vasodilator and contractile factors by the endothelium, which in turn triggers early pulmonary vasoconstriction and later pulmonary vascular remodeling. The mechanism of the occurrence is extremely complex. However, there is no cure for HPH at present. The research on the regulation mechanism and intervention of HPH has become an urgent scientific problem to be solved. This article reviews the role of κ-opioid receptor in the occurrence and development of HPH, aiming to introduce the latest progress of κ-opioid receptor in related research fields.