AIM  To investigate the correlation between vascular cell adhesion molecule 1 (VCAM-1) and the prognosis of patients with ischemic heart failure (IHF) and non-IHF.

METHODS A total of 208 patients with chronic HF who were hospitalized in the Cardiovascular Department of Hebei Provincial People’s Hospital from March 2019 to March 2020 were selected and they were divided into the IHF group (n=92) and the non-IHF group (n=116) according to the etiology. The clinical data and the concentration level of VCAM-1 were compared between the two groups. The patients were sub-grouped according to the occurrence of all-cause death within 3 years and COX regression was used to analyze the prognosis in the different groups.

RESULTS ① There was no statistically significant difference in VCAM-1 levels between the IHF group and the non IHF group. The VCAM-1 levels in the group with all cause mortality in IHF patients were higher than those in the group without all cause mortality (P<0.01), while there was no significant difference in VCAM-1 levels between the two groups with and without all cause mortality in non IHF patients; ② Multivariate COX regression analysis showed that VCAM-1 (HR=1.005, 95% CI: 1.001～1.009, P<0.05) and left ventricular ejection fraction (HR=0.908, 95% CI: 0.830～0.993, P<0.05) were the influencing factors for all-cause mortality in IHF patients; ③ Multivariate COX regression analysis showed that VCAM-1 was not a factor for all-cause mortality in non IHF patients (HR=0.998, 95% CI: 0.995～1001, P=0.998).

CONCLUSION VCAM-1 is significantly associated with the prognosis of IHF patients and high levels of VCAM-1 increase the risk of all-cause mortality in patients with IHF.