AIM  To explore the predictive value of serum complement C1q tumor necrosis factor related protein 9 (CTRP9) and potential transforming growth factor β binding protein 2 (LTBP-2) for major adverse cardiovascular events (MACE) in elderly patients with chronic heart failure (CHF).

METHODS 150 elderly CHF patients diagnosed through examination and admitted to the Affiliated Cardiovascular Hospital of Qingdao University from August 2020 to October 2021 were selected as the study subjects. The patients were followed up for 12 months, with 45 patients in the MACE group and 105 patients in the non MACE group. Compare the serum levels of CTRP9 and LTBP-2 between the MACE group and the non MACE group patients. The predictive value of ROC curve analysis of CTRP9 and LTBP-2 for MACE in elderly CHF patients. Logistic regression analysis of factors affecting the occurrence of MACE in elderly CHF patients.

RESULTS Compared with the non MACE group, the MACE group had higher levels of LVEDD, LVESD, BNP, and lower levels of LVEF (all P<0.01). The serum LTBP-2 level increased, while the CTRP9 level decreased (both P<0.01). ROC analysis showed that the AUC for evaluating MACE occurrence based on serum CTRP9 levels was 0.772, with a cutoff value of 137.50 μg/L, sensitivity of 73.30%, specificity of 66.70%; The AUC of MACE assessed by LTBP-2 level is 0.771, with a cutoff value of 20.02 μg/L, sensitivity is 71.10%, specificity is 61.90%. The sensitivity of the combined detection of the two is 84.40%, specificity is 80.00%, and AUC is 0.889 (95% CI: 0.838～0.940). Multivariate logistic regression analysis showed that LTBP-2 was a risk factor for MACE in patients, while CTRP9 was a protective factor (all P<0.01).

CONCLUSION Serum CTRP9 and LTBP-2 have certain diagnostic value in evaluating the occurrence of MACE in elderly CHF patients.