Abstract:
AIM To investigate the correlation between plasma Proprotein convertase subtilisin/kexin type 9 (PCSK9) and homocysteine (Hcy) in patients with acute coronary syndrome (ACS).
METHODS A total of 105 patients diagnosed with ACS who were hospitalized in the Heart Center of General Hospital of Ningxia Medical University from January to December 2022 were selected, and the subjects were divided into normal Hcy group and hyperhomocysteinemia (HHcy) group according to plasma Hcy level. Clinical data, laboratory indicators, coronary angiography data, and plasma PCSK9 and Hcy levels were collected. Pearson correlation analysis and multi-factor linear regression method were conducted to analyze the correlation between PCSK9 and Hcy.
RESULTS Compared with the normal group, the proportion of males in HHcy group was higher (P<0.05), the estimated glomerular filtrationrate (eGFR) and high density lipoprotein cholesterol (HDL-C) were decreased (P<0.05), and interleukin-1 (IL-1) (P<0.05), interleukin-6 (IL-6) (P<0.01), tumor necrosis factor α (TNFα) (P<0.05) and PCSK9 (P<0.01) were increased. The SYNTAX score was higher (P<0.05) in HHcy group than in the normal group (P<0.05). The results of Pearson linear correlation analysis showed that PCSK9 was positively correlated with Hcy level (r=0.4126, P<0.01), and the correlation was more significant in females (the correlation was 0.7320 in females (P<0.001) and 0.3567 in males (P<0.01). Multivariate regression analysis showed that after adjusting for sex, age and other clinical indicators, Compared with normal group, PCSK9 level increased by 2.941pg/ml for every 1μmol/L increase in plasma Hcy level (95%CI: 1.293, 4.588, P<0.01) and level of PCSK9 in HHcy group was increased by 71.277 pg/ml (95%CI: 13.350, 129.204, P<0.05).
CONCLUSION There is a positive correlation between plasma PCSK9 and Hcy in ACS patients, and the correlation is more significant in female patients.