Abstract: Myocardial ischemia-reperfusion injury (MIRI) typically occurs after direct percutaneous coronary intervention (PCI). MIRI has intricate mechanisms that can potentially harm the structure and function of cardiomyocytes, ultimately resulting in apoptosis and necrosis. Investigating the occurrence and progression of apoptosis, a crucial mechanism in MIRI, is of great significance for the clinical prognosis of acute myocardial infarction (AMI) patients. The endoplasmic reticulum and mitochondria play crucial roles in cardiomyocytes, participating in a variety of physiological activities. MAMs, rich in multiple protein complexes, bridge the two vital organelles. MAMs play a role in regulating diverse cellular physiological activities, particularly apoptosis. This article reviews relevant research on cell apoptosis in MIRI and explores its correlation with MAMs, aiming to provide assistance for the clinical treatment of MIRI.