自噬在肺动脉高压中的作用及研究进展

Role and research progress of autophagy in pulmonary hypertension

摘要: 肺动脉高压(pulmonary hypertension，PH) 是一种进行性的、严重的肺血管系统疾病，以肺血管阻力增加和肺血管重塑为特点，以右心衰竭或死亡为终点，严重威胁我国高原驻训官兵的健康。近几年研究发现，肺动脉高压受到多种自噬相关通路的调控，本文主要阐述了重要的自噬相关蛋白，并简要介绍以此为基础的治疗方案。

Abstract: Pulmonary hypertension is a progressive and serious disease of the pulmonary vascular system. It is characterized by increased pulmonary vascular resistance and pulmonary vascular remodeling, with right heart failure or death as the end point. In particular, it seriously threatens the health of officers and soldiers stationed at high altitudes in China. In recent years, studies have found that pulmonary hypertension is regulated by a variety of autophagy-related pathways. This review mainly expounds the important autophagy-related proteins, and briefly introduces the treatment plan based on this.