心脏肥大中心肌能量代谢重构的研究进展

    Research progress of myocardial energy metabolism remodeling in cardiac hypertrophy

    • 摘要: 心脏维持收缩功能需要消耗大量能量,因此能量代谢对心脏功能至关重要。心脏能量代谢重构大多从能量供应角度考虑,然而心脏肥大中心肌能量代谢重构的结果并不局限于能量供应不足,中间产物的变化对心脏功能的影响也同样重要。从能量代谢角度研究则可能为心脏肥大挖掘一些预防和治疗的新靶点。本文首先概述了心脏肥大时心肌的能量代谢变化,再对近几年关于能量代谢中间产物对心脏功能影响的最新研究进行综述。

       

      Abstract: The heart needs to use a lot of energy to maintain systolic function, so energy metabolism is crucial for the heart function. The remodeling of cardiac energy metabolism is mostly considered from the perspective of energy supply. However, the results of myocardial energy metabolism remodeling in cardiac hypertrophy are not limited to impaired energy supply, and the influence of intermediate products on cardiac function is equally important. The study from the perspective of energy metabolism may explore some new targets for the prevention and treatment of cardiac hypertrophy. In this paper, the changes of myocardial energy metabolism during cardiac hypertrophy were summarized and the recent studies on the effects of energy metabolism intermediates on the cardiac function were reviewed.

       

    /

    返回文章
    返回