Abstract:
Once exposed to the harsh environmental conditions in high altitude, cardiovascular system will undergo a series of adaptive changes to better complete oxygen delivery and energy metabolism, so as to resist the adverse effects of high altitude and meet the body’s needs. The present paper gives a comprehensive review about the pathophysiological changes of the cardiovascular system at high altitude, the molecular mechanisms of myocardial adaptation to high altitude, and the recommendations for patients with cardiovascular diseases at high altitude. We intend to provide a theoretical basis for the intervention and treatment of cardiovascular diseases at high altitude, thus helping to improve the health level and working capacity of people at high altitude.