高原心血管系统适应性改变的研究进展

    Research progress in adaptive changes of cardiovascular system in plateau

    • 摘要: 暴露于高原严苛的环境条件时,心血管系统会产生一系列适应性改变以更好的完成氧气输送、能量代谢等,从而抵抗高原带来的不利影响、满足机体需求。本文通过对高原心血管系统的病理生理学变化、高原心肌适应的分子机制、合并心血管疾病患者的高原建议三个方面进行综述,拟为高原心血管疾病的干预及治疗提供理论依据,进而有助于提高高原健康水平和作业能力。

       

      Abstract: Once exposed to the harsh environmental conditions in high altitude, cardiovascular system will undergo a series of adaptive changes to better complete oxygen delivery and energy metabolism, so as to resist the adverse effects of high altitude and meet the body’s needs. The present paper gives a comprehensive review about the pathophysiological changes of the cardiovascular system at high altitude, the molecular mechanisms of myocardial adaptation to high altitude, and the recommendations for patients with cardiovascular diseases at high altitude. We intend to provide a theoretical basis for the intervention and treatment of cardiovascular diseases at high altitude, thus helping to improve the health level and working capacity of people at high altitude.

       

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