活性氧在缺氧性肺动脉高压发病机制中的作用

    Role of reactive oxygen species in pathogenesis of hypoxic pulmonary hypertension

    • 摘要: 活性氧(reactive oxygen species,ROS)作为正常的细胞代谢产物,是各种生理病理机制中的重要信号分子。研究表明,ROS作为调节肺血管张力和功能的重要介质,可通过调控离子通道、蛋白激酶以及其他信号分子来参与肺血管舒缩反应以及肺动脉平滑肌细胞和内皮细胞的功能稳态,在HPH的发生发展中起重要作用。本文主要阐述ROS在肺血管收缩和肺血管重塑中的作用机制,为HPH的防治提供新思路。

       

      Abstract: As a normal cellular metabolite, reactive oxygen species (ROS) is an important signaling molecule in various physiological and pathological mechanisms. Studies have shown that ROS, as an important mediator of regulating pulmonary vascular tone and function, plays an important role in the occurrence and development of hypoxic pulmonary artery hypertension by regulating ion channels, protein kinases and other signaling molecules to participate in pulmonary vasomotor response as well as functional homeostasis of pulmonary artery smooth muscle cells and endothelial cells. This paper mainly expounds the mechanism of ROS in pulmonary vasoconstriction and pulmonary vascular remodeling, and provides new ideas for the prevention and treatment of hypoxic pulmonary artery hypertension.

       

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