Abstract:
As a normal cellular metabolite, reactive oxygen species (ROS) is an important signaling molecule in various physiological and pathological mechanisms. Studies have shown that ROS, as an important mediator of regulating pulmonary vascular tone and function, plays an important role in the occurrence and development of hypoxic pulmonary artery hypertension by regulating ion channels, protein kinases and other signaling molecules to participate in pulmonary vasomotor response as well as functional homeostasis of pulmonary artery smooth muscle cells and endothelial cells. This paper mainly expounds the mechanism of ROS in pulmonary vasoconstriction and pulmonary vascular remodeling, and provides new ideas for the prevention and treatment of hypoxic pulmonary artery hypertension.