靳嘉岩, 刘赫, 曹桂花, 刘艳, 王晓明, 侯莉明. 离子通道在糖尿病心肌病中研究新进展[J]. 心脏杂志, 2023, 35(1): 83-87. DOI: 10.12125/j.chj.202206040
    引用本文: 靳嘉岩, 刘赫, 曹桂花, 刘艳, 王晓明, 侯莉明. 离子通道在糖尿病心肌病中研究新进展[J]. 心脏杂志, 2023, 35(1): 83-87. DOI: 10.12125/j.chj.202206040
    Jia-yan JIN, He LIU, Gui-hua CAO, Yan LIU, Xiao-ming WANG, Li-ming HOU. Research progress of alternations of ion channels in diabetes cardiomyopathy[J]. Chinese Heart Journal, 2023, 35(1): 83-87. DOI: 10.12125/j.chj.202206040
    Citation: Jia-yan JIN, He LIU, Gui-hua CAO, Yan LIU, Xiao-ming WANG, Li-ming HOU. Research progress of alternations of ion channels in diabetes cardiomyopathy[J]. Chinese Heart Journal, 2023, 35(1): 83-87. DOI: 10.12125/j.chj.202206040

    离子通道在糖尿病心肌病中研究新进展

    Research progress of alternations of ion channels in diabetes cardiomyopathy

    • 摘要: 糖尿病性心肌病(diabetes cardiomyopathy,DCM)是继发于糖尿病的一种特异性心肌病,其独立于高血压性、冠状动脉粥样硬化性或其他原因所致心脏病。DCM以心肌代谢紊乱和心脏微血管病变为基础,导致广泛的局灶性心肌坏死,随后发展为收缩功能障碍,最终表现为心力衰竭。离子通道在维持心肌细胞膜电位、信号传导、心肌细胞代谢方面发挥着重要作用,近年来的研究发现,钙、钾、钠等阳离子通道以及阴离子通道的改变是糖尿病心肌病发病的重要基础。本文从离子通道这一视角出发,系统性综述了糖尿病心肌病研究新进展。

       

      Abstract: Diabetes cardiomyopathy (DCM) is a myocardial disease that occurs in diabetic patients and is different from hypertensive heart disease, coronary atherosclerotic heart disease or other cardiac lesions. On the basis of metabolic disorder and microvascular disease, this disease leads to extensive focal necrosis of myocardium, subclinical cardiac dysfunction, and eventually progresses to heart failure, arrhythmia and cardiogenic shock, and even sudden death in severe patients. Ion channels play important roles in maintaining the functions of normal cardiomyocytes, including maintaining the stability of cell membrane potential, normal heart rhythm conduction, myocardial contraction and energy metabolism of cardiomyocytes. In diabetic cardiomyopathy, ion channels are closely related to arrhythmias, ventricular remodeling and heart failure. Over the past years, prominent changes in K+, Na+, Ca2+ and anion channels have been found to play important roles in the regulation of diabetic cardiac functions. Here, we focus on diabetic cardiomyopathy from an ion channel perspective and summarize recent findings to discuss the contributions of ion channel to pathological functions in DCM.

       

    /

    返回文章
    返回