Abstract: Pulmonary arterial hypertension, a type of pulmonary hypertension, is characterized by increased pulmonary arterial pressure and pulmonary vascular resistance, leading to right heart failure and death. Prostacyclin signaling pathway is one of the important pathways of pulmonary arterial hypertension. In addition to prostacyclin analogs and prostacyclin IP receptor agonists, drugs acting on thromboxane A2 are also under study. In addition, more new therapeutic drugs are entering clinical trials. This paper briefly introduces the above drugs in order to provide reference for the treatment of pulmonary hypertension.