Abstract: IL-37, a novel anti-inflammatory factor, has recently been shown to protect against vascular calcification and arteriosclerosis, as well as other calcification reactions such as valve calcification. IL-37 can inhibit the inflammatory reaction and the autoimmune reaction, and it also has some effect on the differentiation of osteoblasts. IL-37 may be a new target to slow down or even treat vascular calcification-related cardiovascular diseases. This article reviews the specific mechanism of IL-37 inhibiting calcification.