韩鹏, 刘浩林, 汪钦, 冯禹楠, 杨茂森, 李成祥, 廉坤. 支链氨基酸水平与充血性心力衰竭患病风险的相关性[J]. 心脏杂志, 2019, 31(4): 417-421. DOI: 10.12125/j.chj.201903003
    引用本文: 韩鹏, 刘浩林, 汪钦, 冯禹楠, 杨茂森, 李成祥, 廉坤. 支链氨基酸水平与充血性心力衰竭患病风险的相关性[J]. 心脏杂志, 2019, 31(4): 417-421. DOI: 10.12125/j.chj.201903003
    Peng HAN, Hao-lin LIIU, Qin WANG, Yu-nan FENG, Mao-sen YANG, Cheng-xiang LI, Kun LIAN. The correlation between elevated levels of branched-chain amino acids and increased risk of congestive heart failure[J]. Chinese Heart Journal, 2019, 31(4): 417-421. DOI: 10.12125/j.chj.201903003
    Citation: Peng HAN, Hao-lin LIIU, Qin WANG, Yu-nan FENG, Mao-sen YANG, Cheng-xiang LI, Kun LIAN. The correlation between elevated levels of branched-chain amino acids and increased risk of congestive heart failure[J]. Chinese Heart Journal, 2019, 31(4): 417-421. DOI: 10.12125/j.chj.201903003

    支链氨基酸水平与充血性心力衰竭患病风险的相关性

    The correlation between elevated levels of branched-chain amino acids and increased risk of congestive heart failure

    • 摘要:
        目的  比较正常健康人群与充血性心力衰竭(congestive heart failure,CHF)患者血浆支链氨基酸(branched-chain amino acids,BCAA)水平变化,并分析BCAA与CHF患病的相关性。
        方法  连续纳入2016年1月至2017年1月西京医院心内科诊断为CHF且左室射血分数(left ventricular ejection fraction,LVEF) < 45%,即收缩期心力衰竭的住院患者150(男120,女30)例作为CHF组,同期纳入在西京医院进行常规体检的健康人100(男70,女30)例作为正常对照组。收集患者临床资料及其他临床生化数据,通过ELISA检测高分子量脂联素(high molecular weight adiponectin,HMW APN)、BCAA等水平的变化,并进一步分析两组间各项指标差异及其相关性。
        结果  CHF患者组的BCAA水平显著高于正常对照组(P < 0.01)。CHF患者组的年龄、体质量指数(body mass index,BMI)、吸烟者比例、高血压患者比例、糖尿病患者比例、肺动脉高压患者比例、血压、BCAA、氨基末端脑钠尿肽(amino-terminal brain natriuretic peptide,NT-proBNP)、脂联素(adiponectin,APN)、HMW APN、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)均表现出升高且差异具有统计学意义(除BMI P < 0.05,其余均P < 0.01),而CHF患者组的血清总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(highdensity lipoprotein cholesterol,HDL-C)、总蛋白(total protein,TP)、白蛋白(albumin,Alb)、LVEF均显著低于正常对照组,差异具有统计学意义(P < 0.01)。在矫正其他可能影响BCAA水平的因素后,CHF患者组血浆BCAA水平显著升高(P < 0.01),CHF患者组BCAA水平与性别和LDL-C(R = −0.193,P = 0.044)分别呈正相关,与HDL-C(R = −0.201,P = 0.0338)呈负相关。并发心肌梗死(myocardial infarction,MI)或心衰所致的室性心律失常(ventricular arrhythmia in heart failure,VAHF)的CHF患者组与未并发MI或VAHF的CHF患者组相比BCAA水平明显升高(P < 0.05)。
        结论  CHF患者组BCAA水平升高,可能与CHF的发生发展呈负相关;BCAA水平与并发MI或VAHF呈正相关。

       

      Abstract:
        AIM  To investigate the correlation between branched-chain amino acids (BCAA) levels and the risk of congestive heart failure (CHF).
        METHODS  Between January 2016 to January 2017, 150 hospitalized patients (120 males and 30 females) diagnosed with congestive hearth failure (CHF) and left ventricular ejection fraction (LVEF) less than 45 in the Department of Cardiology of Xijing Hospital were included as the CHF group. Meanwhile, 100 healthy people (70 males and 30 females) who had routine physical examination in Xijing Hospital were included as the control group. Biochemical data and clinical data of the study population were collected and further analyzed for correlation.
        RESULTS  BCAA level in the CHF group was significantly higher than that in the normal control group (P < 0.01). Age, body mass index (BMI), proportion of smokers, proportion of hypertension patients, proportion of diabetes patients, proportion of pulmonary hypertension patients, blood pressure, BCAA, amino-terminal brain natriuretic peptide, NT-proBNP, adiponectin (APN), HMW APN, triglyceride (TG), low density lipoprotein cholesterol (LDL-C) all showed elevated levels and the differences were statistically significant (P < 0.05). However, the serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), total protein (TP), albumin (Alb) and LVEF in CHF group were significantly lower than those in the normal control group, and the difference was statistically significant (P < 0.01). After correcting other factors that may affect the BCAA level, the plasma BCAA level in the CHF patient group increased significantly (P < 0.01). The BCAA level in the CHF patient group was positively correlated with gender and LDL-C(R=-0.193, P=0.044), respectively, and negatively correlated with HDL-C(R=-0.201, P=0.0338). The BCAA level of CHF patients with myocardial infarction (MI) or ventricular arrhythMIa (ventricular arrhythmia in heart failure (VAHF) was significantly higher than that of CHF patients without MI or VAHF (P < 0.05).
        CONCLUSION  The increase of BCAA levels in CHF patients was negatively correlated with the occurrence and development of CHF. BCAA levels were negatively correlated with HDL-C level and positively correlated with LDC-C level and combined MI or VAHF.

       

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