Abstract: Myocardial infarction is an acute ischemic heart disease that can be complicated by arrhythmia, shock and heart failure. In severe cases, it will endanger the lives of patients. Its pathological features are myocardial vascular stenosis and blockage caused by various reasons, which will lead to myocardial infarction. Angiogenesis is one of the effective methods for the treatment of myocardial infarction. In recent years, with research on angiogenic factors and angiogenesis, therapeutic angiogenesis has become a new research field of post-myocardial treatment and plays an important role in restoring revascularization. Methods for therapeutic angiogenesis include protein therapy, gene therapy and cell therapy. This article reviews the application of therapeutic angiogenesis after myocardial infarction.