王志敏, 王建智, 倪宁. 民航飞行人员同型半胱氨酸与高血压病的关系及其与血脂的相关性[J]. 心脏杂志, 2019, 31(3): 320-322, 326. DOI: 10.12125/j.chj.201807043
    引用本文: 王志敏, 王建智, 倪宁. 民航飞行人员同型半胱氨酸与高血压病的关系及其与血脂的相关性[J]. 心脏杂志, 2019, 31(3): 320-322, 326. DOI: 10.12125/j.chj.201807043
    Zhi-min WANG, Jian-zhi WANG, Ning NI. Relationship of homocysteine and essential hypertension in civil aviation pilots[J]. Chinese Heart Journal, 2019, 31(3): 320-322, 326. DOI: 10.12125/j.chj.201807043
    Citation: Zhi-min WANG, Jian-zhi WANG, Ning NI. Relationship of homocysteine and essential hypertension in civil aviation pilots[J]. Chinese Heart Journal, 2019, 31(3): 320-322, 326. DOI: 10.12125/j.chj.201807043

    民航飞行人员同型半胱氨酸与高血压病的关系及其与血脂的相关性

    Relationship of homocysteine and essential hypertension in civil aviation pilots

    • 摘要:
        目的  分析同型半胱氨酸(homocysteine,Hcy)与原发性高血压(高血压病)的关系及其Hcy与血脂的相关性。
        方法  28例健康体检者为对照组,38例高血压病患者为高血压病组,高血压病组又分为调脂组20例和未调脂组18例。分别测定各组受试对象血浆Hcy及血脂指标。
        结果  与对照组比较,高血压组Hcy水平显著升高(P<0.01);与未调脂组比较,调脂组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)显著降低(P <0.01),但Hcy水平下降不显著;Pearson相关性分析显示:调脂组Hcy与三项血脂指标TC、LDL-C、ApoB均无相关性。
        结论  高Hcy血症(HHcy)是民航飞行员高血压患者的危险因素;Hcy与TC、LDL-C水平无相关性,调脂治疗并不能够改善血浆Hcy水平。

       

      Abstract:
        AIM  To study levels of homocysteine and blood lipids in patients with essential hypertension. To investigate the relationship between homocysteine and hypertension. To analyze the correlation between serum lipids and homocysteine.
        METHODS  28 healthy patients were placed in a control group and 38 hypertensive patients were placed in a hypertension group. The hypertension group was divided into a lipid- regulating therapy group (20 cases) and a non-lipid-regulating therapy group (18 cases). Homocysteine, total cholesterol, low density lipoprotein, apolipoprotein B were measured.
        RESULTS  Compared with the control group, homocysteine levels in the hypertension group increased significantly (P < 0.05). Compared with the non-lipid-regulating group, total cholesterol, low densitylipoprotein and apolipoprotein B were significantly decreased (P < 0.05); however, homocysteine levels were not significantly decreased in the lipid regulating group; Correlation analysis of Pearson showed that homocysteine was not related to the blood lipid index in the lipid regulating group.
        CONCLUSION  Hyperhomocysteinemia is a risk factor in essential hypertension. Homocysteine is not correlated with total cholesterol and low-density lipoprotein. Lipid-regulating therapy does not improve plasma homocysteine levels.

       

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