谷阳, 刘万波, 陈雨, 徐海, 卢周舟, 张喜文. 脂蛋白相关磷脂酶A2与早发冠心病的相关性及其临床意义[J]. 心脏杂志, 2019, 30(1): 28-30, 33. DOI: 10.12125/j.chj.201806037
    引用本文: 谷阳, 刘万波, 陈雨, 徐海, 卢周舟, 张喜文. 脂蛋白相关磷脂酶A2与早发冠心病的相关性及其临床意义[J]. 心脏杂志, 2019, 30(1): 28-30, 33. DOI: 10.12125/j.chj.201806037
    Yang GU, Wan-bo LIU, Yu CHEN, Hai XU, Zhou-zhou LU, Xi-wen ZHANG. The correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance[J]. Chinese Heart Journal, 2019, 30(1): 28-30, 33. DOI: 10.12125/j.chj.201806037
    Citation: Yang GU, Wan-bo LIU, Yu CHEN, Hai XU, Zhou-zhou LU, Xi-wen ZHANG. The correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance[J]. Chinese Heart Journal, 2019, 30(1): 28-30, 33. DOI: 10.12125/j.chj.201806037

    脂蛋白相关磷脂酶A2与早发冠心病的相关性及其临床意义

    The correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance

    • 摘要:
        目的   研究早发冠心病患者的危险因素,探讨脂蛋白相关磷脂酶(Lp-PL)A2水平与早发冠心病的相关性及临床意义。
        方法   选取因胸痛住院并行冠状动脉造影,确诊为早发冠心病的患者63例。选取同期行冠脉造影,血管管腔狭窄<50%的患者30例作为对照组。分析Lp-PL A2水平与GRACE风险评分和Gensini积分的相关性。Logistic回归分析早发冠心病的危险因素。
        结果   ①早发冠心病组的脂蛋白相关磷脂酶A2水平显著高于对照组(P<0.05)。②早发冠心病患者的脂蛋白相关磷脂酶A2水平与Gensini积分、GRACE风险评分显著相关(r=0.368,P<0.05;r=0.402,P<0.05)。③Logistic回归结果显示Lp-PL A2水平是早发冠心病的独立相关因素(P<0.05)。
        结论   PL-PL A2水平是早发冠心病的独立相关因素,与冠状动脉病变严重程度呈正相关,对评估早发冠心病的风险具有重要的临床应用价值。

       

      Abstract:
        AIM   To study risk factors of patients with premature coronary heart disease and to investigate the correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance.
        METHODS   93 patients underwent coronary angiography were divided into premature coronary heart disease group (n=63) and a control group (coronary artery stenosis <50%, n=30). The Lp-PLA2 levels were investigated between the two groups and the relationship of Lp-PLA2 with risk of patients was studied.
        RESULTS   Lp-PLA2 levels were significantly higher in premature coronary heart disease group than in the control group(P<0.05). Lp-PLA2 had a significant correlation with Gensini score (r=0.368,P<0.05) and GRACE risk score (r=0.402,P<0.05). Multivariate logistic regression analysis showed that Lp-PLA2 was independently associated with premature coronary heart disease (P<0.05).
        CONCLUSION   Lp-PLA2 is independently associated with premature coronary heart disease and positively related with the severity of coronary artery and prognosis. Thus Lp-PLA2 can be used as a predictor of risk assessment in premature coronary heart disease patients.

       

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