唐园园, 李冰石. 血清尿酸与慢性心力衰竭患者预后的相关性及其预测价值[J]. 心脏杂志, 2020, 32(2): 131-134. DOI: 10.12125/j.chj.201512018
    引用本文: 唐园园, 李冰石. 血清尿酸与慢性心力衰竭患者预后的相关性及其预测价值[J]. 心脏杂志, 2020, 32(2): 131-134. DOI: 10.12125/j.chj.201512018
    Yuan-yuan TANG, Bing-shi LI. Correlation of serum uric acid and the prognosis of patients with chronic heart failure and its predictive value[J]. Chinese Heart Journal, 2020, 32(2): 131-134. DOI: 10.12125/j.chj.201512018
    Citation: Yuan-yuan TANG, Bing-shi LI. Correlation of serum uric acid and the prognosis of patients with chronic heart failure and its predictive value[J]. Chinese Heart Journal, 2020, 32(2): 131-134. DOI: 10.12125/j.chj.201512018

    血清尿酸与慢性心力衰竭患者预后的相关性及其预测价值

    Correlation of serum uric acid and the prognosis of patients with chronic heart failure and its predictive value

    • 摘要:
        目的  分析血清尿酸(UA)与慢性心力衰竭(CHF)患者预后的相关性及其预测价值。
        方法  入选CHF患者60例,随访1年,按随访期内是否发生心血管事件分为事件组(n = 21)和非事件组(39),做UA与CHF患者预后的相关性分析,并用ROC曲线初步评价UA对CHF预后的预测价值。
        结果  事件组和非事件组UA水平分别为(486 ± 70)μmol/L和(338±86)μmol/L(P<0.01);与非事件组比较,事件组患者左室舒张末期内径(LVEDD),左房内径(LAD),房颤发生率显著增加,左室射血分数(LVEF)显著下降(P<0.01)。多因素分析显示:UA是CHF患者预后的独立相关因素,Pearson相关性分析结果显示,UA与年龄、尿素氮、肌酐、氨基末端脑钠肽前体及心血管不良事件发生率呈正相关(分别为r = 0.12、r = 0.26、r = 0.21和r = 0.24,r = 0.31.均P<0.01);与LVEF值呈负相关(r = −0.56,P<0.01)。以UA数值445 μmol/L为截断点,UA数值预测心血管不良事件发生率的灵敏度为85%,特异度为98%,准确度为93%。
        结论  UA是CHF患者预后的独立相关因素,UA对CHF心血管不良事件发生的预测是有价值的。

       

      Abstract:
        AIM  To assess correlation between serum uric acid (UA) and prognosis in patients with congestive heart failure (CHF) and its predictive value.
        METHODS  60 patients with CHF were divided into a cardiovascular event group (n = 21) and a non-cardiovascular event group (n = 39) based on the major adverse cardiovascular events during one-year follow up. The correlation between UA and the prognosis of patients with CHF were analyzed, and the preliminary evaluation using ROC curve for predictive value of prognosis.
        RESULTS  The level of UA in events group and non-event group were 486 ± 70 μmol/L and 338 + 86 μmol/L (P < 0.01). Compared with non-event group, levels of left ventricular end-diastolic diameter (LVEDD), left atrial diameter (LAD) and incidence of atrial fibrillation were increase asignificantly, left ventricular ejection fraction (LVEF) decreased significantly (P < 0.01). Multiple Factors analysis showed that UA was an independent factor associated with the prognosis of patients with CHF. Pearson correlation analysis showed that the levels of UA were positively correlated with age, urea nitrogen, creatinine, NT-proBNP and adverse cardiovascular events. (r = 0.12、0.26、0.21、0.24、0.31, all P < 0.01), and negatively correlated with LVEF (r = −0.56, P < 0.01). At the optimum cutoff point of 445 μmol/l, the sensitivity and specificity of UA predicting cardiovascular events were 85% and 98%, the accuracy was 93%, respectively.
        CONCLUSION  Serum uric acid is associated with prognosis in CHF patients. Hyperuricemia is an independent risk factor for patients with heart failure.

       

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