Clinical value and study on the relationship between non-high-density lipoprotein cholesterol and early major adverse cardiovascular events in patients with acute coronary syndrome

AIM To analyze the relationship between non-high-density lipoprotein cholesterol (non-HDL-C) and early major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS). METHODSEnrolled in this study were 408 ACS patients. According to occurrence of MACE, 408 patients were divided into two groups: event group (n=63) and nonevent group (n=345). Serum lipid levels and characteristics of the two groups were analyzed. RESULTSBaseline level of non-HDL-C in patients with MACE was higher than in patients without MACE ［(3.5±0.7) mmol/L vs.(3.1±0.9) mmol/L, P<0.05］. Multivariable logistic regression analysis showed that non-HDL-C, high-sensitivity C-reactive protein (hs-CRP), red blood cell distribution width (RWD) and age are risk factors for MACE. Receiver operating characteristic curve (ROC) analysis showed that the optimal cut-off value of non-HDL-C was 3.31 mmol/L, with a sensitivity of 68.3% and specificity of 64.3%. CONCLUSIONNon-HDL-C is an independent risk factor for ACS and can be used to predict the occurrence of early MACE in ACS patients.