The role of C1q/TNF-related protein-3 (CTRP-3) in patients with acute coronary syndrome

AIM To analyze the relationship between C1q/TNF-related protein-3 (CTRP-3) and acute coronary syndrome (ACS). METHODSWe examined circulating CTRP-3 levels in 206 ACS patients and 208 patients with stable angina pectoris (SAP). RESULTSCompared with those in SAP patients, CTRP-3 levels significantly decreased in ACS patients. Correlation analysis adjusted for age and gender exhibited that CTRP-3 concentrations showed a significant negative relationship with glucose (r=-0.121, P<0.01) and hsCRP levels (r=-0.152, P<0.01) and a positive relationship with HDL-cholesterol (r=0.112, P<0.01) and adiponectin (APN) levels (r=0.136, P<0.01). Logistic analysis revealed that APN was negatively associated with ACS (r=-0.45, P<0.05) and after correcting some factors it was still negatively associated with ACS (r=-0.38, P<0.05). CTRP3 was not only negatively associated with ACS (r=-0.34, P<0.05) but also negatively associated with ACS after correcting some factors (r=-0.22, P<0.05). CONCLUSIONCTRP3 and APN are associated with ACS.