Effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy

AIM:To evaluate the effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy (DCM). METHODS: Thirty patients with DCM were treated with continuous subcutaneous insulin injection. SOD, GSH-PX and MDA were compared before and after insulin pump therapy. RESULTS: After treatment, SOD and GSH-PX levels significantly increased, whereas the MDA level significantly decreased (P<0.01). CONCLUSION: Oxidative stress level in DCM patients significantly decreases after continuous subcutaneous insulin injection treatment.