Correlation between serum levels of SDF-1α and TGF-β1 and degree of coronary artery stenosis in patients with different types of coronary artery disease

AIM To explore the correlation between the serum levels of SDF-1α and TGF-β1 and different types of coronary artery diseases as well as the degree of stenosised coronary artery. METHODS A total of 124 patients were divided into four groups: 32 cases were diagnosed as stable angina pectoris (SAP), 30 cases as unstable angina pectoris (UAP), 32 cases as acute myocardial infarction (AMI), and a control group of 30 cases who had been identified by as having no coronary diseases by coronary angiography. The serum level of SDF-1α and TGF-β1 were determined by ELISA assay and following coronary angiography, the degree of coronary artery stenosis was determined by Gensini’s scores system. RESULTS ① The serum levels of SDF-1α and TGF-β1 in each coronary heart disease group were significantly lower than those in control group (P<0.01). The levels in UAP and AMI groups were lower than in those in SAP group (P<0.01) and the levels in AMI group were lower compared with those the UAP group (P<0.01). ②The correlation indexes in UAP, SAP and AMI groups were respectively -0.31 (P=0.0749), -0.69(P=0.0036) and -0.76(P=0.0049) between the serum levels of SDF-1α and the coronary artery Gensini’s scores. The correlation indexes in UAP, SAP and AMI groups were respectively -0.19(P=0.1529), -0.71(P=0.0037) and -0.77(P=0.0029) between the serum level of TGF-β1 and the coronary artery Gensini’s scores. ③The serum levels of SDF-1α and TGF-β1 were significantly different between unicoronary artery stenosis, bicoronary artery stenosis and tricoronary artery stenosis (P<0.01), and the serum levels of SDF-1α and TGF-β1 were negatively correlated with the number of stenosised coronary artery（r=-0.65, P=0.0218； r=-0.73, P=0.0065）. CONCLUSION The serum levels of SDF-1α and TGF-β1 in the coronary heart disease group are lower than those in the control group and are negatively correlated with the severity of coronary artery disease and the stenosised degree of coronary arteries.