Serum lipid peroxidation levels in patients with coronary slow flow

AIM: To observe the levels of serum lipid peroxidation in patients with coronary slow flow (CSF) and to study related factors. METHODS: Thirty-five patients with documented CSF defined according to TIMI frame count method (TFC) and 35 patients with normal coronary flow were enrolled. Levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malonyldialdehyde (MDA) and lipid peroxidation (LPO) were determined by biochemistry and logistic regression analysis was performed. RESULTS: Baseline data showed that compared with control group, MDA and LPO significantly increased in CSF group ［MDA: (18.9±2.0) vs.(10.5±1.3) mol/L, P<0.01］, ［LPO: (2.8±0.4) vs.(1.9±0.2) mol/L, P<0.01］. Serum GSH-PX also increased in CSF group ［GSH-PX: (0.22±0.04) vs.(0.20±0.03) mol/L, P<0.05］, but SOD significantly decreased in CSF group ［SOD: (72±11) vs.(79±10) kU/L, P<0.01］. After calibration of body mass index, total cholesterol and blood urea nitrogen, analysis showed that CSF was positively correlated with GSH-PX, MDA and LPO (β=1.768, 1.565 and 1.204, respectively, P<0.05, P<0.01, P<0.01) but was negatively correlated with SOD (β=0.115, P<0.05). CONCLUSION: In CSF patients, serum SOD decreases, whereas MDA, LPO and GSH-PX increase. The increased peroxide products of MDA, LPO and GSH-PX enhance oxidative stress in the body, which may result in CSF.