Analysis of in-hospital mortality difference between male and female patients with acute ST-segment elevation myocardial infarction

AIM: To analyze the in-hospital mortality difference between male and female patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS: A retrospective analysis of clinical data was conducted in 1 278 patients with first STEMI who were admitted to our institution within 24 h of symptom onset. RESULTS: Compared with males, females were older and had a higher incidence of hypertension and diabetes mellitus and higher levels of fasting plasma glucose, total cholesterol and low-density lipoprotein cholesterol. Fewer women took angiotensin-converting enzyme (ACE) inhibitors, β-blockers, or statins or had percutaneous coronary intervention. Logistic regression analysis revealed that age, hypertension, fasting plasma glucose and lower use of ACE inhibitors, β-blockers and percutaneous coronary intervention were independently associated with in-hospital mortality in patients with acute STEMI. CONCLUSION: Higher in-hospital mortality after an acute STEMI in women can be explained by older age, more concomitant diseases and less aggressive treatment.