Research progress of induced pluripotent stem cells in in vitro models of arrhythmogenic diseases

Arrhythmogenic diseases can be life threatening. Many genetic arrhythmias are caused by gene mutations. As an in vitro model to study hereditary arrhythmogenic diseases, induced pluripotent stem cellderived cardiomyocytes (iPSC-CMs) are induced by somatic cells obtained from patients, offering new insight into the study of arrhythmia pathogenesis.This paper mainly reviews the generation process of the induced cardiomyocytes from iPSCs and the iPS models of arrhythmogenic diseases including long QT syndrome, catecholaminedependent ventricular tachycardia and arrhythmogenic right ventricular cardiomyopathy.