Correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide in patients with chronic heart failure

AIM:To study the correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide (PICP) in patients with different classifications of chronic heart failure (CHF). METHODS: Sixty patients were equally divided into three groups: NYHA I group, NYHA II group, and NYHA III group (n=20 in each group). Expressions of HSP47 and PICP in serum were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum concentration of PICP in the NYHA II group was significantly higher than in the NYHA I group and the concentration of serum PICP in NYHA III group was significantly higher than in the NYHA II group (both P<0.05). A positive correlation was found between expression of HSP47 and PICP. CONCLUSION: Myocardial fibrosis and left ventricular diameter are positively correlated, suggesting that myocardial fibrosis plays an important role in ventricular remodeling. HSP47 and PICP in blood-serum have a significantly positive correlation in patients with CHF.