Association of -1562C>T polymorphism of matrix metalloproteinase-9 gene and coronary artery disease: a meta-analysis

AIM:To evaluate the relationship of matrix metalloproteinase-9 gene -1562 C>T polymorphisms with coronary artery disease (CAD). METHODS: A literature search was conducted in PubMed, Elsevier, EMbase, and CNKI database to identify eligible case-control studies published before November 30, 2012 on the relationship between matrix metalloproteinase-9 gene -1562 C>T polymorphism and CAD. The odds ratios of all the studies were combined, dependent on the results of heterogeneity tests among the individual studies. Review Manager (v.5.0) and Stata (v.11.0) were used for meta-analysis. RESULTS: A total of 13 case-control studies were identified. No publication bias was identified in the 13 reviewed studies. The summarized odds ratios of TT and CT genotype combination vs. CC genotype across all 13 studies was OR=1.29 (95%, CI 1.13-1.47, P<0.01), T genotype vs. C genotype was OR=1.27 (95%, CI 1.13-1.42, P<0.01), and CT genotype vs. CC and TT genotype combination was OR=1.29 (95%, CI 1.13-1.48, P<0.01). CONCLUSION: C>T polymorphism of the matrix metalloproteinase-9 gene -1562 is associated with CAD. T allele of matrix metalloproteinase-9 gene may be the susceptibility marker for CAD.