Research progress of PI3K/Akt signaling pathway in regulating cardiac functions

PI3K/Akt signaling pathway is an important signal pathway in regulating cardiac functions. PI3K/Akt signaling pathway is involved in regulation of cardiac functions through vascular endothelial growth factor (VEGF)-mediated angiogenesis, inhibition of myocardial apoptosis, ventricular remodeling and promoting energy metabolism. This review briefly summarizes PI3K/Akt signaling pathway mediated molecular mechanisms of regulating cardiac functions.