Relationship between PPARγ and coronary heart disease and acute myocardial infarction in diabetes

AIM: To study the relationship between serum PPARγ level and coronary heart disease (CHD) and acute myocardial infarction (AMI) in type II diabetes mellitus (T2DM). METHODS: Patients diagnosed as having CHD by coronary artery opacification were divided into four groups: stable angina pectoris group (SAP), unstable angina pectoris group (UAP), AMI group, and AMI/T2DM group (AD). Subjects relieved from CHD by coronary artery opacification were selected as control group. Venous blood of all study subjects was taken to determine PPARγ, blood lipids and fasting blood glucose. RESULTS: No significant difference was found in PPARγ level between SAP group and control group. PPARγ levels in SAP group, UA group, AMI group and AD group were significantly lower than in control group (P<0.01). CONCLUSION: PPARγ level in patients with AMI complicated by T2DM is obviously lower than in patients with AMI.