Prevalence and risk factors of clopidogrel resistance after percutaneous coronary intervention in patients over 60 years of age

AIM: To assess the incidence and risk factors of clopidogrel resistance after percutaneous coronary intervention (PCI) with drug-eluting stent in patients >60 years of age. METHODS: The clinical data of 208 patients were collected, among whom 55 patients whose PAR >50% after PCI were assigned to the clopidogrel resistance group and the other 153 patients were assigned to the without resistance group. Correlation factors were analyzed and compared between groups. RESULTS: The incidence of clopidogrel resistance was 26.4% in elderly patients. The level of PAR was (57±6)% vs. (35±9)% (P<0.01) between the two groups after PCI. Multivariate logistic regression models found that the risk factor was diabetes mellitus (P=0.037, OR 2.053, 95% CI 1.045-4.034). CONCLUSION: The incidence of clopidogrel resistance is 26.4% after PCI with drug-eluting stent in patients >60 years of age, and diabetes mellitus is the risk factor for clopidogrel resistance.